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Article

Alternative Splicing Increases Sirtuin Gene Family Diversity and Modulates Their Subcellular Localization and Function.

International journal of molecular sciences - 6 Jan 2021

Zhang Xiaomin, Ameer Fathima S, Azhar Gohar, Wei Jeanne Y

Abstract excerpt

Alternative splicing generates multiple distinct isoforms that increase transcriptome and proteome diversity. There are seven sirtuin genes in humans, each consists of multiple exons that are likely to undergo alternative splicing. Our aim was to characterize the effect of alternative splicing on the sirtuin genes. Here, we report the identification of 23 human sirtuin isoforms, most of which were not previously...

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PMID: 33418837
DOI: 10.3390/ijms22020473
PMCID: PMC7824890

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