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Article

A functional polymorphism of the GTP cyclohydrolase 1 gene predicts attention performance.

Neuroscience letters - 30 Apr 2014

Yasuda Yuka, Hashimoto Ryota, Ohi Kazutaka, Yamamori Hidenaga, Fujimoto Michiko, Umeda-Yano Satomi, Fujino Haruo, Fukunaga Masaki, Horiguchi Mieko, Takeda Masatoshi, Ichinose Hiroshi

Abstract excerpt

Guanosine triphosphate cyclohydrolase 1 (GCH1) is the rate-limiting enzyme for the biosynthesis of tetrahydrobiopterin, a cofactor for aromatic amino acid hydroxylases and nitric oxide synthases. As monoamine neurotransmitters are synthesized by the reactions catalyzed by tyrosine hydroxylase and tryptophan hydroxylase, alterations in the content of tetrahydrobiopterin affect the monoamine levels in the brain....

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Source

Identifiers

PMID: 24561090
DOI: 10.1016/j.neulet.2014.02.019

Genes

GCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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