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Article

Tryptophan hydroxylase 1 gene polymorphisms alter prefrontal cortex activation during response inhibition.

Neuropsychology - 1 Jan 2016

Ruocco Anthony C, Rodrigo Achala H, Carcone Dean, McMain Shelley, Jacobs Grace, Kennedy James L

Abstract excerpt

OBJECTIVE: The tryptophan hydroxylase 1 gene (TPH1) catalyzes the formation of 5-hydroxytryptophan, a precursor to the neurotransmitter serotonin. Variations in the gene encoding this enzyme may underlie difficulties in impulse control; however, the proximate relationship between risk alleles for polymorphisms in the TPH1 gene and the neural correlates of response inhibition remain poorly understood. The present...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26710093
DOI: 10.1037/neu0000237

Genes

TPH1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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