Article
ARID1A mutations in endometriosis-associated ovarian carcinomas.
The New England journal of medicine - 14 Oct 2010
Wiegand Kimberly C, Shah Sohrab P, Al-Agha Osama M, Zhao Yongjun, Tse Kane, Zeng Thomas, Senz Janine, McConechy Melissa K, Anglesio Michael S, Kalloger Steve E, Yang Winnie, Heravi-Moussavi Alireza, Giuliany Ryan, Chow Christine, Fee John, Zayed Abdalnasser, Prentice Leah, Melnyk Nataliya, Turashvili Gulisa, Delaney Allen D, Madore Jason, Yip Stephen, McPherson Andrew W, Ha Gavin, Bell Lynda, Fereday Sian, Tam Angela, Galletta Laura, Tonin Patricia N, Provencher Diane, Miller Dianne, Jones Steven J M, Moore Richard A, Morin Gregg B, Oloumi Arusha, Boyd Niki, Aparicio Samuel A, Shih Ie-Ming, Mes-Masson Anne-Marie, Bowtell David D, Hirst Martin, Gilks Blake, Marra Marco A, Huntsman David G
Abstract excerpt
BACKGROUND: Ovarian clear-cell and endometrioid carcinomas may arise from endometriosis, but the molecular events involved in this transformation have not been described. METHODS: We sequenced the whole transcriptomes of 18 ovarian clear-cell carcinomas and 1 ovarian clear-cell carcinoma cell line and found somatic mutations in ARID1A (the AT-rich interactive domain 1A [SWI-like] gene) in 6 of the samples. ARID1A...
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