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The Y99C Mutation in Guanylyl Cyclase-Activating Protein 1 Increases Intracellular Ca<sup>2+</sup>and Causes Photoreceptor Degeneration in Transgenic Mice

7 Jul 2004

Abstract excerpt

Guanylyl cyclase-activating proteins (GCAPs) are Ca2+-binding proteins that activate guanylyl cyclase when free Ca2+ concentrations in retinal rods and cones fall after illumination and inhibit the cyclase when free Ca2+ reaches its resting level in the dark. Several forms of retinal dystrophy are caused by mutations in GUCA1A, the gene coding for GCAP1. To investigate the cellular mechanisms affected by the...

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PMID: 15240799
DOI: 10.1523/jneurosci.0963-04.2004

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