Article
Treatment of congenital fibrinogen deficiency: overview and recent findings.
Vascular health and risk management - 1 Jan 2009
Tziomalos Konstantinos, Vakalopoulou Sofia, Perifanis Vassilios, Garipidou Vassilia
Abstract excerpt
Afibrinogenemia is a rare bleeding disorder with an estimated prevalence of 1:1,000,000. It is an autosomal recessive disease resulting from mutations in any of the 3 genes that encode the 3 polypeptide chains of fibrinogen and are located on the long arm of chromosome 4. Spontaneous bleeding, bleeding after minor trauma and excessive bleeding during interventional procedures are the principal manifestations. We...
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