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Article

Filamin B represses chondrocyte hypertrophy in a Runx2/Smad3-dependent manner.

The Journal of cell biology - 2 Jul 2007

Zheng Lihua, Baek Hwa-Jin, Karsenty Gerard, Justice Monica J

Abstract excerpt

FILAMIN B, which encodes a cytoplasmic actin binding protein, is mutated in several skeletal dysplasias. To further investigate how an actin binding protein influences skeletogenesis, we generated mice lacking intact Filamin B. As observed in spondylocarpotarsal synostosis syndrome patients, Filamin B mutant mice display ectopic mineralization in many cartilaginous elements. This aberrant mineralization is due to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17606870
DOI: 10.1083/jcb.200703113
PMCID: PMC2064428

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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