The filamin-B–refilin axis – spatiotemporal regulators of the actin-cytoskeleton in development and disease

Abstract excerpt

ABSTRACT During development, cycles of spatiotemporal remodeling of higher-order networks of actin filaments contribute to control cell fate specification and differentiation. Programs for controlling these dynamics are hard-wired into actin-regulatory proteins. The filamin family of actin-binding proteins exert crucial mechanotransduction and signaling functions in tissue morphogenesis. Filamin-B (FLNB) is a key...

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