Mitochondrial DNA variant in COX1 subunit significantly alters energy metabolism of geographically divergent wild isolates in Caenorhabditis elegans.

doi:10.1016/j.jmb.2014.02.009

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Article

Mitochondrial DNA variant in COX1 subunit significantly alters energy metabolism of geographically divergent wild isolates in Caenorhabditis elegans.

Journal of molecular biology - 29 May 2014

Dingley Stephen D, Polyak Erzsebet, Ostrovsky Julian, Srinivasan Satish, Lee Icksoo, Rosenfeld Amy B, Tsukikawa Mai, Xiao Rui, Selak Mary A, Coon Joshua J, Hebert Alexander S, Grimsrud Paul A, Kwon Young Joon, Pagliarini David J, Gai Xiaowu, Schurr Theodore G, Hüttemann Maik, Nakamaru-Ogiso Eiko, Falk Marni J

Abstract excerpt

Mitochondrial DNA (mtDNA) sequence variation can influence the penetrance of complex diseases and climatic adaptation. While studies in geographically defined human populations suggest that mtDNA mutations become fixed when they have conferred metabolic capabilities optimally suited for a specific environment, it has been challenging to definitively assign adaptive functions to specific mtDNA sequence variants in...

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PMID: 24534730
DOI: 10.1016/j.jmb.2014.02.009
PMCID: PMC4067970

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