Article
Natural variation in life history and aging phenotypes is associated with mitochondrial DNA deletion frequency in Caenorhabditis briggsae.
BMC evolutionary biology - 12 Jan 2011
Estes Suzanne, Coleman-Hulbert Anna L, Hicks Kiley A, de Haan Gene, Martha Sarah R, Knapp Jeremiah B, Smith Samson W, Stein Kevin C, Denver Dee R
Abstract excerpt
BACKGROUND: Mutations that impair mitochondrial functioning are associated with a variety of metabolic and age-related disorders. A barrier to rigorous tests of the role of mitochondrial dysfunction in aging processes has been the lack of model systems with relevant, naturally occurring mitochondrial genetic variation. Toward the goal of developing such a model system, we studied natural variation in life...
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