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Article

Divergence in a master variator generates distinct phenotypes and transcriptional responses.

Genes & development - 15 Feb 2014

Gallagher Jennifer E G, Zheng Wei, Rong Xiaoqing, Miranda Noraliz, Lin Zhixiang, Dunn Barbara, Zhao Hongyu, Snyder Michael P

Abstract excerpt

Genetic basis of phenotypic differences in individuals is an important area in biology and personalized medicine. Analysis of divergent Saccharomyces cerevisiae strains grown under different conditions revealed extensive variation in response to both drugs (e.g., 4-nitroquinoline 1-oxide [4NQO]) and different carbon sources. Differences in 4NQO resistance were due to amino acid variation in the transcription...

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Identifiers

PMID: 24532717
DOI: 10.1101/gad.228940.113
PMCID: PMC3937518

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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