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Article

Absence of A673T variant in APP gene indicates an alternative protective mechanism contributing to longevity in Chinese individuals.

Neurobiology of aging - 1 Apr 2014

Liu Yao-Wen, He Yong-Han, Zhang Yun-Xia, Cai Wang-Wei, Yang Li-Qin, Xu Liang-You, Kong Qing-Peng

Abstract excerpt

A673T, a rare variant in the amyloid-β precursor protein gene, shows a protective potential against Alzheimer's disease (AD) and age-related cognitive decline in an Icelandic population. Although A673T was observed independently in a Finnish population, this variant was absent in 8721 Asian subjects. The conflicting observations suggest that the contribution of A673T may be confined to Europeans and Americans...

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Source

Identifiers

PMID: 24126161
DOI: 10.1016/j.neurobiolaging.2013.09.023

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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