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Article

Loss of PI3K p110α in the Adipose Tissue Results in Infertility and Delayed Puberty Onset in Male Mice.

BioMed research international - 1 Jan 2017

Nelson Victoria L Boughton, Negrón Ariel L, Reid Inefta, Thomas Justin A, Yang Leon, Lin Richard Z, Acosta-Martínez Maricedes

Abstract excerpt

Deletion of PI3K catalytic subunit p110α in adipose tissue (aP2-Cre/p110αflx/flx, α-/- hereafter) results in increased adiposity, glucose intolerance, and liver steatosis. Because this endocrine organ releases hormones like leptin, which are important in reproductive physiology, we investigated the reproductive phenotype of α-/- males. Compared to controls, α-/- males displayed delayed onset of puberty...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28357399
DOI: 10.1155/2017/3756089
PMCID: PMC5357525

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