Article
The mouse ruby-eye 2(d) (ru2(d) /Hps5(ru2-d) ) allele inhibits eumelanin but not pheomelanin synthesis.
Pigment cell & melanoma research - 1 Sept 2013
Hirobe Tomohisa, Ito Shosuke, Wakamatsu Kazumasa
Abstract excerpt
The novel mutation named ru2(d) /Hps5(ru2-d) , characterized by light-colored coats and ruby-eyes, prohibits differentiation of melanocytes by inhibiting tyrosinase (Tyr) activity, expression of Tyr, Tyr-related protein 1 (Tyrp1), Tyrp2, and Kit. However, it is not known whether the ru2(d) allele affects pheomelanin synthesis in recessive yellow (e/Mc1r(e) ) or in pheomelanic stage in agouti (A) mice. In this...
Topics
- Alleles
- Animals
- Genes, Recessive
- Hair
- Melanins
- Mice
- Pigmentation
- Proteins