Article
Association between amylin and amyloid-β peptides in plasma in the context of apolipoprotein E4 allele.
PloS one - 1 Jan 2014
Qiu Wei Qiao, Wallack Max, Dean Michael, Liebson Elizabeth, Mwamburi Mkaya, Zhu Haihao
Abstract excerpt
Amylin, a pancreatic peptide that readily crosses the blood brain barrier (BBB), and amyloid-beta peptide (Aβ), the main component of amyloid plaques and a major component of Alzheimer's disease (AD) pathology in the brain, share several features. These include having similar β-sheet secondary structures, binding to the same receptor, and being degraded by the same protease. Thus, amylin may be associated with...
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