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Article

Inherent instability of the retinitis pigmentosa P23H mutant opsin.

The Journal of biological chemistry - 28 Mar 2014

Chen Yuanyuan, Jastrzebska Beata, Cao Pengxiu, Zhang Jianye, Wang Benlian, Sun Wenyu, Yuan Yiyuan, Feng Zhaoyang, Palczewski Krzysztof

Abstract excerpt

The P23H opsin mutation is the most common cause of autosomal dominant retinitis pigmentosa. Even though the pathobiology of the resulting retinal degeneration has been characterized in several animal models, its complex molecular mechanism is not well understood. Here, we expressed P23H bovine rod opsin in the nervous system of Caenorhabditis elegans. Expression was low due to enhanced protein degradation. The...

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Identifiers

PMID: 24515108
DOI: 10.1074/jbc.M114.551713
PMCID: PMC3979360

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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