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Article

MAF mediates crosstalk between Ras-MAPK and mTOR signaling in NF1.

Oncogene - 4 Dec 2014

Brundage M E, Tandon P, Eaves D W, Williams J P, Miller S J, Hennigan R H, Jegga A, Cripe T P, Ratner N

Abstract excerpt

Mutations in the neurofibromatosis type 1 (NF1) tumor suppressor gene are common in cancer and can cause resistance to therapy. Using transcriptome analysis we identified MAF as an NF1- regulated transcription factor and verified MAF regulation through RAS/MAPK/AP-1 signaling in malignant peripheral nerve sheath tumor (MPNST) cell lines. MAF was also downregulated in human MPNST. Acute re-expression of MAF...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to TOR Serine-Threonine Kinases

Source

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Identifiers

PMID: 24509877
DOI: 10.1038/onc.2013.506
PMCID: PMC4127377

Genes

MAF
DEPTOR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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