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Article

Radiosensitization of glioma cells by TP53-induced glycolysis and apoptosis regulator knockdown is dependent on thioredoxin-1 nuclear translocation.

Free radical biology & medicine - 1 Apr 2014

Zhang Haowen, Gu Cheng, Yu Jiahua, Wang Zhongmin, Yuan Xiaopeng, Yang Lei, Wang Jie, Jia Yanshuang, Liu Jianjun, Liu Fenju

Abstract excerpt

TP53-induced glycolysis and apoptosis regulator (TIGAR) knockdown is proven to radiosensitize glioma cells, but the mechanisms are not fully understood. Thioredoxin-1 (TRX1) is a redox-sensitive oxidoreductase, which plays critical roles in DNA damage signal transduction via nuclear translocation in irradiated cells. Because the TRX1-dependent DNA damage signaling pathway relies on NADPH to maintain the reduced...

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PMID: 24509157
DOI: 10.1016/j.freeradbiomed.2014.01.034

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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