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Article

Loss of Gsx1 and Gsx2 function rescues distinct phenotypes in Dlx1/2 mutants.

The Journal of comparative neurology - 1 May 2013

Wang Bei, Long Jason E, Flandin Pierre, Pla Ramon, Waclaw Ronald R, Campbell Kenneth, Rubenstein John L R

Abstract excerpt

Mice lacking the Dlx1 and Dlx2 homeobox genes (Dlx1/2 mutants) have severe deficits in subpallial differentiation, including overexpression of the Gsx1 and Gsx2 homeobox genes. To investigate whether Gsx overexpression contributes to the Dlx1/2 mutant phenotypes, we made compound loss-of-function mutants. Eliminating Gsx2 function from the Dlx1/2 mutants rescued the increased expression of Ascl1 and Hes5 (Notch...

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Identifiers

PMID: 23042297
DOI: 10.1002/cne.23242
PMCID: PMC3615175

Genes

GAD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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