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Article

Chloptosin, an Apoptosis-Inducing Dimeric Cyclohexapeptide Produced by Streptomyces

29 Dec 1999

Abstract excerpt

In the course of screening for apoptosis-inducing agents, chloptosin (1) was isolated from the culture broth of Streptomyces. The dumbbell-type structure of the dimeric cyclohexapeptide consisting of D-valine, (3S)- and (3R)-piperazic acids, O-methyl-L-serine, D-threonine, and (2S,3aR,8aR)-6-chloro-3a-hydroxy-2,3,3a, 8a-hexahydropyrrolo[2,3-b]indole-2-carboxylic acid was elucidated by spectroscopic and chemical...

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PMID: 10813957
DOI: 10.1021/jo991314b

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