Article
Hypoxic induction of vascular endothelial growth factor (VEGF) and angiogenesis in muscle by truncated peroxisome proliferator-activated receptor γ coactivator (PGC)-1α.
The Journal of biological chemistry - 28 Mar 2014
Thom Robyn, Rowe Glenn C, Jang Cholsoon, Safdar Adeel, Arany Zoltan
Abstract excerpt
The transcriptional coactivator peroxisome proliferator-activator receptor γ coactivator (PGC)-1α is required for full hypoxic induction of vascular endothelial growth factor (VEGF) in skeletal muscle cells. Under normoxic conditions, PGC-1α also strongly induces mitochondrial biogenesis, but PGC-1α does not activate this program under hypoxic conditions. How this specificity is achieved is not known. We show...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.