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Article

PGC-1alpha plays a functional role in exercise-induced mitochondrial biogenesis and angiogenesis but not fiber-type transformation in mouse skeletal muscle.

American journal of physiology. Cell physiology - 1 Mar 2010

Geng Tuoyu, Li Ping, Okutsu Mitsuharu, Yin Xinhe, Kwek Jyeyi, Zhang Mei, Yan Zhen

Abstract excerpt

Endurance exercise stimulates peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha) expression in skeletal muscle, and forced expression of PGC-1alpha changes muscle metabolism and exercise capacity in mice. However, it is unclear if PGC-1alpha is indispensible for endurance exercise-induced metabolic and contractile adaptations in skeletal muscle. In this study, we showed that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha

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Source

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Identifiers

PMID: 20032509
DOI: 10.1152/ajpcell.00481.2009
PMCID: PMC3353735

Genes

PGC
SOD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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