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Article

The transcriptional coactivator PGC-1α mediates exercise-induced angiogenesis in skeletal muscle

4 Dec 2009

Abstract excerpt

Peripheral arterial disease (PAD) affects 5 million people in the US and is the primary cause of limb amputations. Exercise remains the single best intervention for PAD, in part thought to be mediated by increases in capillary density. How exercise triggers angiogenesis is not known. PPARgamma coactivator (PGC)-1alpha is a potent transcriptional co-activator that regulates oxidative metabolism in a variety of...

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PMID: 19966219
DOI: 10.1073/pnas.0909131106

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