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Article

Flavivirus NS1 Structures Reveal Surfaces for Associations with Membranes and the Immune System

6 Feb 2014

Abstract excerpt

Flaviviruses, the human pathogens responsible for dengue fever, West Nile fever, tick-borne encephalitis, and yellow fever, are endemic in tropical and temperate parts of the world. The flavivirus nonstructural protein 1 (NS1) functions in genome replication as an intracellular dimer and in immune system evasion as a secreted hexamer. We report crystal structures for full-length, glycosylated NS1 from West Nile...

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PMID: 24505133
DOI: 10.1126/science.1247749

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