Article
Interaction between the α-barrel tip of Vibrio vulnificus TolC homologs and AcrA implies the adapter bridging model.
Journal of microbiology (Seoul, Korea) - 1 Feb 2014
Lee Seunghwa, Song Saemee, Lee Minho, Hwang Soonhye, Kim Ji-Sun, Ha Nam-Chul, Lee Kangseok
Abstract excerpt
The AcrAB-TolC multidrug efflux pump confers resistance to Escherichia coli against many antibiotics and toxic compounds. The TolC protein is an outer membrane factor that participates in the formation of type I secretion systems. The genome of Vibrio vulnificus encodes two proteins homologous to the E. coli TolC, designated TolCV1 and TolCV2. Here, we show that both TolCV1 and TolCV2 partially complement the E....
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