Article
Amino acid addition to Vibrio cholerae LPS establishes a link between surface remodeling in gram-positive and gram-negative bacteria.
Proceedings of the National Academy of Sciences of the United States of America - 29 May 2012
Hankins Jessica V, Madsen James A, Giles David K, Brodbelt Jennifer S, Trent M Stephen
Abstract excerpt
Historically, the O1 El Tor and classical biotypes of Vibrio cholerae have been differentiated by their resistance to the antimicrobial peptide polymyxin B. However, the molecular mechanisms associated with this phenotypic distinction have remained a mystery for 50 y. Both gram-negative and gram-positive bacteria modify their cell wall components with amine-containing substituents to reduce the net negative...
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