Article
A broad-spectrum human lung fibroblast-derived mitogen is a variant of hepatocyte growth factor.
Proceedings of the National Academy of Sciences of the United States of America - 15 Jan 1991
Rubin J S, Chan A M, Bottaro D P, Burgess W H, Taylor W G, Cech A C, Hirschfield D W, Wong J, Miki T, Finch P W
Abstract excerpt
A heparin-binding mitogen was isolated from conditioned medium of human embryonic lung fibroblasts. It exhibited broad target-cell specificity whose pattern was distinct from that of any known growth factor. It rapidly stimulated tyrosine phosphorylation of a 145-kDa protein in responsive cells, suggesting that its signaling pathways involved activation of a tyrosine kinase. Purification identified a major...
Topics
- Amino Acid Sequence
- Animals
- Cell Line
- Cloning, Molecular
- DNA
- DNA Replication
- Enzyme Activation
- Fibroblasts
- Genetic Variation
- Growth Substances
- Hepatocyte Growth Factor