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Article

Chemical rescue and inhibition studies to determine the role of Arg301 in phosphite dehydrogenase.

PloS one - 1 Jan 2014

Hung John E, Fogle Emily J, Garg Neha, Chekan Jonathan R, Nair Satish K, van der Donk Wilfred A

Abstract excerpt

Phosphite dehydrogenase (PTDH) catalyzes the NAD(+)-dependent oxidation of phosphite to phosphate. This reaction requires the deprotonation of a water nucleophile for attack on phosphite. A crystal structure was recently solved that identified Arg301 as a potential base given its proximity and orientation to the substrates and a water molecule within the active site. Mutants of this residue showed its importance...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24498026
DOI: 10.1371/journal.pone.0087134
PMCID: PMC3909101

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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