Article
Engineering water to act as an active site acid catalyst in a soluble fumarate reductase.
Biochemistry - 8 Oct 2002
Mowat Christopher G, Pankhurst Katherine L, Miles Caroline S, Leys David, Walkinshaw Malcolm D, Reid Graeme A, Chapman Stephen K
Abstract excerpt
The ability of an arginine residue to function as the active site acid catalyst in the fumarate reductase family of enzymes is now well-established. Recently, a dual role for the arginine during fumarate reduction has been proposed [Mowat, C. G., Moysey, R., Miles, C. S., Leys, D., Doherty, M. K., Taylor, P., Walkinshaw, M. D., Reid, G. A., and Chapman, S. K. (2001) Biochemistry 40, 12292-12298] in which it acts...
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