Article
Specific contactin N-glycans are implicated in neurofascin binding and autoimmune targeting in peripheral neuropathies.
The Journal of biological chemistry - 14 Mar 2014
Labasque Marilyne, Hivert Bruno, Nogales-Gadea Gisela, Querol Luis, Illa Isabel, Faivre-Sarrailh Catherine
Abstract excerpt
Cell adhesion molecules (CAMs) play a crucial role in the formation of the nodes of Ranvier and in the rapid propagation of the nerve impulses along myelinated axons. These CAMs are the targets of autoimmunity in inflammatory neuropathies. We recently showed that a subgroup of patients with aggressive chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) shows autoantibodies to contactin (1). The...
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