Neurofascin IgG4 antibodies in CIDP associate with disabling tremor and poor response to IVIg.

doi:10.1212/WNL.0000000000000205

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Article

Neurofascin IgG4 antibodies in CIDP associate with disabling tremor and poor response to IVIg.

Neurology - 11 Mar 2014

Querol Luis, Nogales-Gadea Gisela, Rojas-Garcia Ricardo, Diaz-Manera Jordi, Pardo Julio, Ortega-Moreno Angel, Sedano Maria Jose, Gallardo Eduard, Berciano Jose, Blesa Rafael, Dalmau Josep, Illa Isabel

Abstract excerpt

OBJECTIVE: To describe the frequency of antibodies against neurofascin in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and the associated clinical features. METHODS: Immunocytochemistry was used to identify antibodies to neurofascin 155 (NF155) and 186. Serum reactivity with paranodes and brain tissue was tested with immunohistochemistry of teased-nerve fibers and rat brain. Antibody titers...

Topics

Adult
Animals
Autoantibodies
Cell Adhesion Molecules
Drug Resistance
Female
HEK293 Cells
Humans
Immunoglobulin G
Immunoglobulins, Intravenous

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Nerve Growth Factors

Phenotype

Polyradiculoneuropathy, Chronic Inflammatory Demyelinating

Rats

Retrospective Studies

Severity of Illness Index

Source

Open in PubMed Open full text

Identifiers

PMID: 24523485
DOI: 10.1212/WNL.0000000000000205
PMCID: PMC3959751

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