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Article

Neurofascin IgG4 antibodies in CIDP associate with disabling tremor and poor response to IVIg.

Neurology - 11 Mar 2014

Querol Luis, Nogales-Gadea Gisela, Rojas-Garcia Ricardo, Diaz-Manera Jordi, Pardo Julio, Ortega-Moreno Angel, Sedano Maria Jose, Gallardo Eduard, Berciano Jose, Blesa Rafael, Dalmau Josep, Illa Isabel

Abstract excerpt

OBJECTIVE: To describe the frequency of antibodies against neurofascin in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and the associated clinical features. METHODS: Immunocytochemistry was used to identify antibodies to neurofascin 155 (NF155) and 186. Serum reactivity with paranodes and brain tissue was tested with immunohistochemistry of teased-nerve fibers and rat brain. Antibody titers...

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PMID: 24523485
DOI: 10.1212/WNL.0000000000000205
PMCID: PMC3959751

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