Article
Zfx mutation results in small animal size and reduced germ cell number in male and female mice.
Development (Cambridge, England) - 1 Jun 1997
Luoh S W, Bain P A, Polakiewicz R D, Goodheart M L, Gardner H, Jaenisch R, Page D C
Abstract excerpt
The zinc-finger proteins ZFX and ZFY, encoded by genes on the mammalian X and Y chromosomes, have been speculated to function in sex differentiation, spermatogenesis, and Turner syndrome. We derived Zfx mutant mice by targeted mutagenesis. Mutant mice (both males and females) were smaller, less viable, and had fewer germ cells than wild-type mice, features also found in human females with an XO karyotype (Turner...
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