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Article

Consequences of glycan truncation on Fc structural integrity

11 Sept 2013

Abstract excerpt

Effective characterization of protein-based therapeutic candidates such as monoclonal antibodies (mAbs) is important to facilitate their successful progression from early discovery and development stages to marketing approval. One challenge relevant to biopharmaceutical development is, understanding how the stability of a protein is affected by the presence of an attached oligosaccharide, termed a glycan. To...

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Share to Glycosylation and Glycoproteins Research
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PMID: 24492344
DOI: 10.4161/mabs.26453

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