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Article

Association of genetic variants with anti-tuberculosis drug induced hepatotoxicity: a high resolution melting analysis.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Apr 2014

Singh Meenakshi, Gupta Vinod H, Amarapurkar Deepak N, Joshi Jyotsna M, Baijal Rajiv, Ramegowda Praveenkumar H, Amarapurkar Anjali D, Wangikar Pramod P

Abstract excerpt

BACKGROUND: Tuberculosis (TB) treatment remains a challenge owing to the high incidence of drug induced hepatotoxicity (DIH). Apart from environmental factors, single nucleotide polymorphisms (SNPs) in drug metabolizing enzymes (DMEs), nuclear receptors (NRs) and transporter proteins (TPs) contribute to DIH. In the present study, we report known and novel SNPs in a total of seven genes of DMEs, NRs and TPs with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24491431
DOI: 10.1016/j.meegid.2014.01.027

Genes

NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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