Inhibition of the K+ channel K(Ca)3.1 reduces TGF-β1-induced premature senescence, myofibroblast phenotype transition and proliferation of mesangial cells.

doi:10.1371/journal.pone.0087410

Article

Inhibition of the K+ channel K(Ca)3.1 reduces TGF-β1-induced premature senescence, myofibroblast phenotype transition and proliferation of mesangial cells.

PloS one - 1 Jan 2014

Fu Rong-Guo, Zhang Tao, Wang Li, Du Yan, Jia Li-Ning, Hou Jing-Jing, Yao Gang-Lian, Liu Xiao-Dan, Zhang Lei, Chen Ling, Gui Bao-Song, Xue Rong-Liang

Abstract excerpt

OBJECTIVE: K(Ca)3.1 channel participates in many important cellular functions. This study planned to investigate the potential involvement of K(Ca)3.1 channel in premature senescence, myofibroblast phenotype transition and proliferation of mesangial cells. METHODS & MATERIALS: Rat mesangial cells were cultured together with TGF-β1 (2 ng/ml) and TGF-β1 (2 ng/ml) + TRAM-34 (16 nM) separately for specified times...

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Inhibition of the K+ channel K(Ca)3.1 reduces TGF-β1-induced premature senescence, myofibroblast phenotype transition and proliferation of mesangial cells.

Abstract excerpt

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