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Article

SOX2 in cancer stemness: tumor malignancy and therapeutic potentials

4 Dec 2018

Abstract excerpt

Cancer stem cells (CSCs), a minor subpopulation of tumor bulks with self-renewal and seeding capacity to generate new tumors, posit a significant challenge to develop effective and long-lasting anti-cancer therapies. The emergence of drug resistance appears upon failure of chemo-/radiation therapy to eradicate the CSCs, thereby leading to CSC-mediated clinical relapse. Accumulating evidence suggests that...

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PMID: 30517668
DOI: 10.1093/jmcb/mjy080

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