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Article

ZFX controls propagation and prevents differentiation of acute T-lymphoblastic and myeloid leukemia.

Cell reports - 13 Feb 2014

Weisberg Stuart P, Smith-Raska Matthew R, Esquilin Jose M, Zhang Ji, Arenzana Teresita L, Lau Colleen M, Churchill Michael, Pan Haiyan, Klinakis Apostolos, Dixon Jack E, Mirny Leonid A, Mukherjee Siddhartha, Reizis Boris

Abstract excerpt

Tumor-propagating cells in acute leukemia maintain a stem/progenitor-like immature phenotype and proliferative capacity. Acute myeloid leukemia (AML) and acute T-lymphoblastic leukemia (T-ALL) originate from different lineages through distinct oncogenic events such as MLL fusions and Notch signaling, respectively. We found that Zfx, a transcription factor that controls hematopoietic stem cell self-renewal,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Isocitrate Dehydrogenase

Share to Kruppel-Like Transcription Factors

Share to Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

Share to Proto-Oncogene Proteins c-myc

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Source

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Identifiers

PMID: 24485662
DOI: 10.1016/j.celrep.2014.01.007
PMCID: PMC3936793

Genes

ZFX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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