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Expression pattern and prognostic implication of zinc homeostasis-related genes in acute myeloid leukemia

14 Apr 2023

Abstract excerpt

Zinc homeostasis is regulated by the SLC39A/ZIP, SLC30A/ZnT, and metallothionein (MT) protein families. The association of zinc homeostasis with acute myeloid leukemia (AML) is unclear. We previously demonstrated that zinc depletion by TPEN triggers apoptosis in NB4 AML cells with the degradation of PML-RARα oncoprotein, suggesting that zinc homeostasis may be associated with AML. The primary aim of this study...

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PMID: 37061789
DOI: 10.1093/mtomcs/mfad022

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