Article
A variational Bayes discrete mixture test for rare variant association.
Genetic epidemiology - 1 Jan 2014
Logsdon Benjamin A, Dai James Y, Auer Paul L, Johnsen Jill M, Ganesh Santhi K, Smith Nicholas L, Wilson James G, Tracy Russell P, Lange Leslie A, Jiao Shuo, Rich Stephen S, Lettre Guillaume, Carlson Christopher S, Jackson Rebecca D, O'Donnell Christopher J, Wurfel Mark M, Nickerson Deborah A, Tang Hua, Reiner Alexander P, Kooperberg Charles
Abstract excerpt
Recently, many statistical methods have been proposed to test for associations between rare genetic variants and complex traits. Most of these methods test for association by aggregating genetic variations within a predefined region, such as a gene. Although there is evidence that "aggregate" tests are more powerful than the single marker test, these tests generally ignore neutral variants and therefore are...
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