Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An evaluation of statistical approaches to rare variant analysis in genetic association studies.

Genetic epidemiology - 1 Feb 2010

Morris Andrew P, Zeggini Eleftheria

Abstract excerpt

Genome-wide association (GWA) studies have proved to be extremely successful in identifying novel common polymorphisms contributing effects to the genetic component underlying complex traits. Nevertheless, one source of, as yet, undiscovered genetic determinants of complex traits are those mediated through the effects of rare variants. With the increasing availability of large-scale re-sequencing data for rare...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosome Mapping
Share to Computer Simulation
Share to Genetic Variation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetics, Population

Share to Genome, Human

Share to Genome-Wide Association Study

Share to Models, Genetic

Share to Models, Statistical

Source

Open in PubMed Open full text

Identifiers

PMID: 19810025
DOI: 10.1002/gepi.20450
PMCID: PMC2962811

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An evaluation of statistical approaches to rare variant analysis in genetic association studies.PMID 19810025Read ↗

Methodology for the analysis of rare genetic variation in genome-wide association and re-sequencing studies of complex human traits.Semantic proximity Read ↗

Rare-variant genome-wide association studies: a new frontier in genetic analysis of complex traits.Semantic proximity Read ↗

RAREsim: A simulation method for very rare genetic variantsSemantic proximity Read ↗

Rare-variant association tests in longitudinal studies, with an application to the Multi-Ethnic Study of Atherosclerosis (MESA).Semantic proximity Read ↗

Rare-variant association analysis: study designs and statistical tests.Semantic proximity Read ↗

RAREsim: A simulation method for very rare genetic variants.Semantic proximity Read ↗

Statistical analysis strategies for association studies involving rare variants.Semantic proximity Read ↗

Selection and explosive growth may hamper the performance of rare variant association testsSemantic proximity Read ↗

Population genetics of rare variants and complex diseases.Semantic proximity Read ↗

Statistical properties of single-marker tests for rare variants.Semantic proximity Read ↗

Association studies for next-generation sequencing.Semantic proximity Read ↗

Properties and modeling of GWAS when complex disease risk is due to non-complementing, deleterious mutations in genes of large effect.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.