Article
Integrative genomic analysis identifies epigenetic marks that mediate genetic risk for epithelial ovarian cancer.
BMC medical genomics - 30 Jan 2014
Koestler Devin C, Chalise Prabhakar, Cicek Mine S, Cunningham Julie M, Armasu Sebastian, Larson Melissa C, Chien Jeremy, Block Matthew, Kalli Kimberly R, Sellers Thomas A, Fridley Brooke L, Goode Ellen L
Abstract excerpt
BACKGROUND: Both genetic and epigenetic factors influence the development and progression of epithelial ovarian cancer (EOC). However, there is an incomplete understanding of the interrelationship between these factors and the extent to which they interact to impact disease risk. In the present study, we aimed to gain insight into this relationship by identifying DNA methylation marks that are candidate mediators...
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