Article
Clonal evolution and clinical correlates of somatic mutations in myeloproliferative neoplasms.
Blood - 3 Apr 2014
Lundberg Pontus, Karow Axel, Nienhold Ronny, Looser Renate, Hao-Shen Hui, Nissen Ina, Girsberger Sabine, Lehmann Thomas, Passweg Jakob, Stern Martin, Beisel Christian, Kralovics Robert, Skoda Radek C
Abstract excerpt
Myeloproliferative neoplasms (MPNs) are a group of clonal disorders characterized by aberrant hematopoietic proliferation and an increased tendency toward leukemic transformation. We used targeted next-generation sequencing (NGS) of 104 genes to detect somatic mutations in a cohort of 197 MPN patients and followed clonal evolution and the impact on clinical outcome. Mutations in calreticulin (CALR) were detected...
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