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Mutations in MPNs: prognostic implications, window to biology, and impact on treatment decisions

2 Dec 2016

Abstract excerpt

The last decade has witnessed tremendous scientific advances, ushered in by the JAK2 V617F discovery, contributing to enhanced diagnostic capability and understanding of the biology of myeloproliferative neoplasms (MPNs). Discovery of the calreticulin mutations filled a diagnostic gap; more recent work sheds light on its contribution to disease pathogenesis, and prognosis. Recent studies have also identified...

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PMID: 27913528
DOI: 10.1182/asheducation-2016.1.552

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