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Article

Reversal of Mycobacterium tuberculosis phenotypic drug resistance by 2-aminoimidazole-based small molecules.

Pathogens and disease - 1 Apr 2014

Ackart David F, Lindsey Erick A, Podell Brendan K, Melander Roberta J, Basaraba Randall J, Melander Christian

Abstract excerpt

The expression of phenotypic drug resistance or drug tolerance serves as a strategy for Mycobacterium tuberculosis to survive in vivo antimicrobial drug treatment; however, the mechanisms are poorly understood. Progress toward a more in depth understanding of in vivo drug tolerance and the discovery of new therapeutic strategies designed specifically to treat drug-tolerant M. tuberculosis are hampered by the lack...

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Identifiers

PMID: 24478046
DOI: 10.1111/2049-632X.12143
PMCID: PMC4367863

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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