Growth of <i>Mycobacterium tuberculosis</i> biofilms containing free mycolic acids and harbouring drug‐tolerant bacteria

Abstract excerpt

Successful treatment of human tuberculosis requires 6-9 months' therapy with multiple antibiotics. Incomplete clearance of tubercle bacilli frequently results in disease relapse, presumably as a result of reactivation of persistent drug-tolerant Mycobacterium tuberculosis cells, although the nature and location of these persisters are not known. In other pathogens, antibiotic tolerance is often associated with...

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