Article

Hyperthermia reduces antimicrobial tolerance of Mycobacterium marinum in biofilms and ex vivo zebrafish granulomas

2025-11-29

Abstract excerpt

The treatment of tuberculosis (TB) is slow and inefficient. One suggested reason for the treatment difficulties are drug-tolerant biofilms that have been shown to develop in TB patients and animal models. In this pioneering pilot study, we explored the potential of hyperthermia in sensitizing biofilm-associated tolerant mycobacteria to antimicrobial agents. As the starting point, we used our newly-developed in vit...

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Literature Corpus work: d1f603bf-f458-52e2-b346-c88115648ee8
DOI: 10.1101/2025.11.28.691154

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