Article
Mutations in the FPIV motif of Newcastle disease virus matrix protein attenuate virus replication and reduce virus budding.
Archives of virology - 1 Jul 2014
Duan Zhiqiang, Hu Zenglei, Zhu Jie, Xu Haixu, Chen Jian, Liu Huimou, Hu Shunlin, Liu Xiufan
Abstract excerpt
The FPIV-like late domains identified in the matrix (M) proteins of parainfluenza virus 5 and mumps virus have been demonstrated to be critical for virus budding. In this study, we found that the same FPIV sequence motif is present in the N-terminus of the Newcastle disease virus (NDV) M protein. Mutagenesis experiments demonstrated that mutation of either phenylalanine (F) or proline (P) to alanine led to a more...
Topics
- Amino Acid Motifs
- Mutation
- Newcastle disease virus
- Viral Matrix Proteins
- Virus Release
- Virus Replication