The glutamic residue at position 402 in the C-terminus of Newcastle disease virus nucleoprotein is critical for the virus.

doi:10.1038/s41598-017-17803-2

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Article

The glutamic residue at position 402 in the C-terminus of Newcastle disease virus nucleoprotein is critical for the virus.

Scientific reports - 12 Dec 2017

Yu Xiaohui, Cheng Jinlong, He Zirong, Li Chuang, Song Yang, Xue Jia, Yang Huiming, Zhang Rui, Zhang Guozhong

Abstract excerpt

The nucleocapsid proteins (NPs) of Newcastle disease virus (NDV) and other paramyxoviruses play an important functional role during genomic RNA replication. Our previous study showed that the NP-encoding gene significantly influenced viral replication. Here, we investigated the roles of certain amino acid residues in the NP C-terminus in viral replication and virulence. Results showed that the glutamic acid...

Topics

Amino Acid Sequence
Animals
Bird Diseases
Cell Line
Chick Embryo
Chickens
Cricetinae
Fibroblasts
Humans
Mutation
Newcastle Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Newcastle disease virus

Nucleocapsid Proteins

Nucleoproteins

RNA, Viral

Viral Proteins

Virulence

Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 29234115
DOI: 10.1038/s41598-017-17803-2
PMCID: PMC5727133

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-29234115-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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