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Article

Ubiquitination on Lysine 247 of Newcastle Disease Virus Matrix Protein Enhances Viral Replication and Virulence by Driving Nuclear-Cytoplasmic Trafficking.

Journal of virology - 26 Jan 2022

Peng Tingyu, Qiu Xusheng, Tan Lei, Yu Shengqing, Yang Binghuan, Dai Jun, Liu Xiaowen, Sun Yingjie, Song Cuiping, Liu Weiwei, Meng Chunchun, Liao Ying, Yuan Weifeng, Ren Tao, Liu Xiufan, Ding Chan

Abstract excerpt

The Newcastle disease virus (NDV) matrix (M) protein is the pivotal element for viral assembly, budding, and proliferation. It traffics through the cellular nucleus but performs its primary function in the cytoplasm. To investigate the biological importance of M protein nuclear-cytoplasmic trafficking and the mechanism involved, the regulatory motif nuclear export signal (NES) and nuclear localization signal...

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Identifiers

PMID: 34705566
DOI: 10.1128/JVI.01629-21
PMCID: PMC8791254

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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