Article
Ubiquitin-regulated nuclear-cytoplasmic trafficking of the Nipah virus matrix protein is important for viral budding.
PLoS pathogens - 11 Nov 2010
Wang Yao E, Park Arnold, Lake Michael, Pentecost Mickey, Torres Betsabe, Yun Tatyana E, Wolf Mike C, Holbrook Michael R, Freiberg Alexander N, Lee Benhur
Abstract excerpt
Paramyxoviruses are known to replicate in the cytoplasm and bud from the plasma membrane. Matrix is the major structural protein in paramyxoviruses that mediates viral assembly and budding. Curiously, the matrix proteins of a few paramyxoviruses have been found in the nucleus, although the biological function associated with this nuclear localization remains obscure. We report here that the nuclear-cytoplasmic...
Topics
- Amino Acid Sequence
- Animals
- Blotting, Western
- Boronic Acids
- Bortezomib
- Cell Nucleus
- Chlorocebus aethiops
- Cytoplasm
- Fluorescent Antibody Technique
- HeLa Cells